发给老马备查:
5 q" r8 o5 z, g& H" C2 P滴水察海(69304838) 15:23:23) C( d9 w8 R! z* a7 h2 X7 |
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
( s M2 R5 m V+ W+ J% p吉非替尼和S-1连用的依据 T- f4 o7 [1 i0 l3 r
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.; _- Y- Q" g4 R/ L
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
% j' `0 A$ `" Q$ k2 v6 _这样是不是推理出,耐药后,可以用S-1和培美了?
6 o& J& O5 k5 G4 b8 Y M5 @结论:
8 X: v% y- ^8 K如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |