发给老马备查:
% H+ u* n# E( L滴水察海(69304838) 15:23:23
6 k8 Q* w L( D+ y% u: m7 ^6 C, |老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 y, w$ K. X# A$ A
吉非替尼和S-1连用的依据' q1 M9 ?/ S. L& I4 w
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! h4 T/ d. R3 J; I3 o
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
7 P5 m6 q3 j( W9 o3 t4 a* J这样是不是推理出,耐药后,可以用S-1和培美了?+ {( t7 L+ [; p, J' @
结论:
" o0 l; w: [! N# `$ N; q# U如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |