发给老马备查:9 [: z8 X, E p/ S: a3 q
滴水察海(69304838) 15:23:23 ! T/ _$ @' o3 B% ]/ J# J V# K( N老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 d _/ u# L) K! Y% P吉非替尼和S-1连用的依据 5 B. L/ X" X* D' x" T8 s* mGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. * z* m: K6 `5 U是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 ' V, Y* h. q: n* w这样是不是推理出,耐药后,可以用S-1和培美了?) i9 R. J- W9 `
结论: e2 Y: @8 E' b# z5 L4 }% c( ~如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。