发给老马备查:) M8 g# n6 W$ ]: L6 Q9 U
滴水察海(69304838) 15:23:23
6 w* F, A# z: F2 [; @老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱1 o' I0 e) [9 R! W
吉非替尼和S-1连用的依据. c# D2 C* n2 r( x2 G# C
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! u$ K7 {' A3 p* q8 V
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达* I1 a& \0 t+ @
这样是不是推理出,耐药后,可以用S-1和培美了?
8 @' p3 r7 _# G' W7 `! O结论:
3 T* U. {5 u, R如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |