Pooled Analysis of S-1 Trials in Non-Small Cell Lung Cancer According to Histological Type' q" H. y) }6 i+ N3 p
NOBUYUKI YAMAMOTO1, TAKEHARU YAMANAKA2, YUKITO ICHINOSE3, KAORU KUBOTA4, HIROSHI SAKAI5, AKIHIKO GEMMA6, NAGAHIRO SAIJO7, MASAHIRO FUKUOKA8 and HISANOBU NIITANI9
' P) e' C7 _! ~% I0 R2 B& R# G+ Author Affiliations
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; v& C2 Z6 h( N' L( c' c6 e1Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan 9 _1 [) [8 y/ g
2Cancer Biostatistics Laboratory, Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811-1395, Japan
& C) [* h6 O6 ~# D/ a2 z/ j' G/ B- m9 Q3Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka 811-1395, Japan - g* ?# }, w0 u( C1 M" j
4Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan $ u! ^& X8 ]+ U
5Division of Thoracic Oncology, Saitama Cancer Center, Saitama 362-0806, Japan ' E- [% [. v* N) [- O
6Division of Pulmonary Medicine, Infectious Diseases, and Oncology Department of Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan
' k7 ~% D, T2 n0 `$ e7 V5 @" \7Kinki University School of Medicine, Osaka 589-8511, Japan
! R; s+ D$ K- c6 z& H8Izumi Municipal Hospital, Osaka 594-0071, Japan
7 U( k% N) |5 y2 Q8 @6 ~' G4 q9Tokyo Cooperative Oncology Group, Tokyo 105-0013, Japan , s" h# j; @5 |' A8 d& u3 G
Correspondence to: Nobuyuki Yamamoto, Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Tel: +81 559895222, Fax: +81 559895783, e-mail: n.yamamoto@scchr.jp
* _/ `0 {! A% r0 E' W* ~AbstractBackground: The antimetabolic agent S-1 inhibits thymidylate synthase similar to pemetrexed, but through a different mechanism of action. Whether the antitumour activity of S-1 depends on histological type remains unclear. We analysed pooled data from 2 phase II clinical studies of cisplatin and S-1 in patients with previously untreated advanced non-small cell lung cancer. Patients and Methods: We comprised 110 patients with stage IIIB or IV non–small cell lung cancer. Univariate and multivariate analyses were performed to determine the effects of histological type on progression-free survival and response rates. Results: On pooled analysis of the data, according to histological type, median progression-free survival was 3.8 months in patients with squamous cell carcinoma and 4.4 months in those with non-squamous cell carcinoma. Both analyses showed that progression-free survival and response rate did not differ significantly. Conclusion: Unlike molecular targeted agents and pemetrexed, a combination of cisplatin and S-1 may be no difference in response according to histological type. * ~4 k, }; n0 |# A: t) s# A
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