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我父亲肺鳞癌的治疗贴(2014年3月1日驾鹤西去)

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1327643 1620 老马 发表于 2011-10-27 08:05:18 | 置顶 |
老马  博士一年级 发表于 2012-4-27 18:50:42 | 显示全部楼层 来自: 浙江温州
Pooled Analysis of S-1 Trials in Non-Small Cell Lung Cancer According to Histological Type' q" H. y) }6 i+ N3 p
NOBUYUKI YAMAMOTO1, TAKEHARU YAMANAKA2, YUKITO ICHINOSE3, KAORU KUBOTA4, HIROSHI SAKAI5, AKIHIKO GEMMA6, NAGAHIRO SAIJO7, MASAHIRO FUKUOKA8 and HISANOBU NIITANI9
' P) e' C7 _! ~% I0 R2 B& R# G+ Author Affiliations
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; v& C2 Z6 h( N' L( c' c6 e1Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan 9 _1 [) [8 y/ g
2Cancer Biostatistics Laboratory, Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811-1395, Japan
& C) [* h6 O6 ~# D/ a2 z/ j' G/ B- m9 Q3Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka 811-1395, Japan - g* ?# }, w0 u( C1 M" j
4Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan $ u! ^& X8 ]+ U
5Division of Thoracic Oncology, Saitama Cancer Center, Saitama 362-0806, Japan ' E- [% [. v* N) [- O
6Division of Pulmonary Medicine, Infectious Diseases, and Oncology Department of Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan
' k7 ~% D, T2 n0 `$ e7 V5 @" \7Kinki University School of Medicine, Osaka 589-8511, Japan
! R; s+ D$ K- c6 z& H8Izumi Municipal Hospital, Osaka 594-0071, Japan
7 U( k% N) |5 y2 Q8 @6 ~' G4 q9Tokyo Cooperative Oncology Group, Tokyo 105-0013, Japan , s" h# j; @5 |' A8 d& u3 G
Correspondence to: Nobuyuki Yamamoto, Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Tel: +81 559895222, Fax: +81 559895783, e-mail: n.yamamoto@scchr.jp
* _/ `0 {! A% r0 E' W* ~AbstractBackground: The antimetabolic agent S-1 inhibits thymidylate synthase similar to pemetrexed, but through a different mechanism of action. Whether the antitumour activity of S-1 depends on histological type remains unclear. We analysed pooled data from 2 phase II clinical studies of cisplatin and S-1 in patients with previously untreated advanced non-small cell lung cancer. Patients and Methods: We comprised 110 patients with stage IIIB or IV non–small cell lung cancer. Univariate and multivariate analyses were performed to determine the effects of histological type on progression-free survival and response rates. Results: On pooled analysis of the data, according to histological type, median progression-free survival was 3.8 months in patients with squamous cell carcinoma and 4.4 months in those with non-squamous cell carcinoma. Both analyses showed that progression-free survival and response rate did not differ significantly. Conclusion: Unlike molecular targeted agents and pemetrexed, a combination of cisplatin and S-1 may be no difference in response according to histological type. * ~4 k, }; n0 |# A: t) s# A

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个人公众号:treeofhope
老马  博士一年级 发表于 2012-4-27 18:52:43 | 显示全部楼层 来自: 浙江温州
S-1 monotherapy for previously treated non-small cell lung cancer: A retrospective analysis by age and histopathological type
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Authors: Yuki Tomita, Tetsuya Oguri, Osamu Takakuwa, Makoto Nakao, Eiji Kunii, Takehiro  Uemura, Hiroaki Ozasa, Mikinori Miyazaki, Ken Maeno, Shigeki Sato
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# n; [2 {# m( U' N# o/ H+ e  A$ PAffiliations: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan  % [. j" h2 a# P: Z

# O9 Q- R: T* f# \' UPublished online on: Thursday, December 1, 2011
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Doi: 10.3892/ol.2011.507 2 _9 r; i: H4 n3 S# t
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Pages: 405-410
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Abstract:
6 I  n# W; F' ~6 ]; d, T" ES-1, an oral fluoropyrimidine derivative, has been approved for the treatment of non-small cell lung cancer (NSCLC) in Japan. In the present study, the efficacy and safety of S-1 monotherapy for elderly patients with previously treated NSCLC were retrospectively evaluated, and the efficacy of S-1 monotherapy was compared by histopathological type. This retrospective study included 54 patients with advanced or recurrent NSCLC who had received S-1 monotherapy following the failure of previous chemotherapy regimens at our institutes. Patient outcomes were compared based on their age and histopathological type. S-1 was administered orally, twice daily, while the duration and interval were modified according to the medical condition of each patient. The default delivery schedule, the mean number of S-1 cycles, did not differ significantly between the two age groups (<70 and ≥70 years). The rate of therapy discontinuation, schedule modification or dose reduction due to intolerable toxicities or patient refusal was relatively frequent in the older group (40.7 and 55.6% for ages <70 and ≥70 years, respectively; p=0.414), and the incidence of grade 3 anemia was relatively high in the older group (3.7 and 18.5%, respectively; p=0.192). The response rates (13.0 and 4.8%, respectively; p=0.609) and disease control rates (39.1 and 33.3%, respectively; p=0.761) did not differ significantly between the two age groups. According to histopathological type, the disease control rate was significantly higher in adenocarcinoma (57.9%) compared to non-adenocarcinoma (20.0%, p=0.013). Thus, S-1 monotherapy may be equally effective and tolerated in patients <70 years and those ≥70 years. Additionally, adenocarcinoma may have a higher disease control rate than non-adenocarcinoma.' w  ~& V' T4 j1 w; p; ?
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个人公众号:treeofhope
老马  博士一年级 发表于 2012-4-27 18:57:27 | 显示全部楼层 来自: 浙江温州
Thymidylate synthase (TS) gene expression in primary lung cancer patients: a large-scale study in Japanese population
6 l3 p- B/ d9 t% g! RF. Tanaka1,*, H. Wada2, Y. Fukui3 and M. Fukushima3
: t  ?6 F, }6 S* Z) F+ Author Affiliations# h* Q/ \4 [/ o8 J6 g! a
1Second Department of Surgery, University of Environmental and Occupational Health, Kitakakyushu 0 Z* l: |# x/ ^& D5 K
2Department of Thoracic Surgery, Kyoto University, Kyoto ' S! ]' A, O" U2 h4 ^* g
3Tokushima Research Center, Taiho Pharmaceutical Co. Ltd, Tokushima, Japan   U% U! W  j, p! w: ~/ M; I6 [8 a
&#8629;*Correspondence to: Dr F. Tanaka, Second Department of Surgery, University of Environmental and Occupational Health, 1-1 Isegaoka, Yahata-nishi, Kitakakyushu, 807-8555, Japan. Tel: +81-93-891-7442; Fax: +81-93-692-4004; E-mail: ftanaka@med.uoeh-u.ac.jp ( t6 ~' I+ D5 o0 \' A, y
Received September 3, 2010.
  d$ H! E, a  G! ~: X2 HRevision received November 11, 2010. & l/ ~% U3 E6 `1 }* ]/ W$ K& |( q
Accepted November 17, 2010.
8 y% o9 u3 G& R$ D1 d6 @2 YAbstract& F+ c4 H3 ?8 M+ L0 X: S
Background: Previous small-sized studies showed lower thymidylate synthase (TS) expression in adenocarcinoma of the lung, which may explain higher antitumor activity of TS-inhibiting agents such as pemetrexed.
4 a9 n. }& K! N. J* o% uPatients and methods: To quantitatively measure TS gene expression in a large-scale Japanese population (n = 2621) with primary lung cancer, laser-captured microdissected sections were cut from primary tumors, surrounding normal lung tissues and involved nodes.
# @1 k) D) q4 N5 C$ M& HResults: TS gene expression level in primary tumor was significantly higher than that in normal lung tissue (mean TS/β-actin, 3.4 and 1.0, respectively; P < 0.01), and TS gene expression level was further higher in involved node (mean TS/β-actin, 7.7; P < 0.01). Analyses of TS gene expression levels in primary tumor according to histologic cell type revealed that small-cell carcinoma showed highest TS expression (mean TS/β-actin, 13.8) and that squamous cell carcinoma showed higher TS expression as compared with adenocarcinoma (mean TS/β-actin, 4.3 and 2.3, respectively; P < 0.01); TS gene expression was significantly increased along with a decrease in the grade of tumor cell differentiation. There was no significant difference in TS gene expression according to any other patient characteristics including tumor progression. 6 n4 I( ~6 {, ~$ J7 o- _9 j
Conclusion: Lower TS expression in adenocarcinoma of the lung was confirmed in a large-scale study.
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个人公众号:treeofhope
走在异乡  高中一年级 发表于 2012-4-28 00:30:22 | 显示全部楼层 来自: 四川成都
一直关注老马的帖子,前方的指明灯。祝福你爸好疗效
累计签到:1 天
连续签到:1 天
[LV.1]初来乍到
baiselianyi  初中二年级 发表于 2012-4-28 10:24:44 | 显示全部楼层 来自: 浙江台州
一直得到老马帮助,祝福老马爸爸
老马  博士一年级 发表于 2012-4-28 18:00:37 | 显示全部楼层 来自: 浙江温州
26日吃了12片地米(0.75mg一片),27日吃了22片地米(0.75mg 一片),28日吃了12片地米(0.75mg一片),都分二次吃。
( l- S7 d# q7 m& a" J7 Y1 u! U今天为止没有任何反应,每天吃VC,VB2,还有漱口水,就怕口腔溃疡。
个人公众号:treeofhope
bishop_cn  大学一年级 发表于 2012-4-28 23:16:11 | 显示全部楼层 来自: 中国
副作用如何,单药反应很小吧?4 L0 }- q; T, ?& ]5 c5 S
老马  博士一年级 发表于 2012-4-29 00:20:00 | 显示全部楼层 来自: 浙江温州
LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy
: b* j. G/ q7 Y1 d# z) ehttp://clinicaltrials.gov/ct2/show/NCT015235878 E8 R; z2 ^% q+ o; `

5 _6 X% i* r! y, T) G# y4 @: K: _) VBIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC
9 z- }. L& c# j) Q3 ^, y' p5 Y3 Shttp://clinicaltrials.gov/ct2/show/NCT01156545
个人公众号:treeofhope
老马  博士一年级 发表于 2012-4-29 20:53:58 | 显示全部楼层 来自: 浙江温州
本帖最后由 老马 于 2012-4-30 09:33 编辑 ! K/ O0 u+ s8 M. M" z, q' N

, g5 {6 y1 F0 Q9 ^; @从4月24日开始到4月28日,打了5天的舒普深(注射用头孢哌酮钠舒巴坦钠),效果非常好。
. V0 g3 b, y. F0 p至今为止,未出现化疗副作用。
个人公众号:treeofhope
英雄武松  大学四年级 发表于 2012-4-30 01:37:05 | 显示全部楼层 来自: 哈萨克斯坦
老马 发表于 2012-4-29 20:53
! ?: J' D& u9 {7 |. S; M! v从4月24日开始到4月28日,打了5天的打了5天舒普深(注射用头孢哌酮钠舒巴坦钠),效果非常好。
! o, w: P8 G" O- j. b至今为止,未出 ...
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没有副作用是第一追求,效果显著是第二追求。
6 i8 ^. E! w# m% F* P不错。

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