看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。8 ?9 E& H9 s7 E7 V9 U& P2 z
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Currently available feasibility data for possible combination strategies.
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4 q2 C' y+ o- i* E! g* _Combination Feasibility according to preliminary data , W, _1 {' F& [' L( @! i; T
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Bevacizumab + sorafenib Yes, reduced dose + m- f* D' @. J" q# U8 L7 r6 D7 l
Bevacizumab + sunitinib† No 4 G8 _7 [6 S2 o) M
Bevacizumab + temsirolimus Yes
+ A( R" u7 V( S. q& k8 j1 i+ TBevacizumab + everolimus Yes
$ Z" o! y" Q) o: KSorafenib + sunitinib ? ) ~5 e2 e: d$ p# s9 m: l. S* N
Sorafenib + temsirolimus Yes, reduced dose
! r1 ~* i1 Y& w: E# J. J$ }- oSorafenib + everolimus Yes, reduced dose
^9 t8 _) v9 U& w0 b% cSunitinib + temsirolimus† No ! ^2 Q( M# m! m2 R. }
Sunitinib + everolimus ? $ M& l4 V* _' E5 w. _
Temsirolimus + everolimus ?
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†Led to US FDA warning.
7 y) _3 K4 P3 s0 ~?: As yet unattempted combination.
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