看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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+ M$ ]3 i/ j$ G$ KCurrently available feasibility data for possible combination strategies. 9 m% ~8 P7 g% q) H8 J3 H- O: }2 u
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0 ^$ Y7 N0 u. gCombination Feasibility according to preliminary data 2 |! m3 W' y7 G2 H% |& V
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, {3 c$ W8 t3 G! H9 ~' X% K$ LBevacizumab + sorafenib Yes, reduced dose
; N& E0 {6 X N1 sBevacizumab + sunitinib† No 7 ]/ i: V& Z o8 _0 B2 w: N2 t9 ~) `! Y
Bevacizumab + temsirolimus Yes ' S5 C- y! j3 n( v2 m5 l) T* m7 `
Bevacizumab + everolimus Yes
2 B" H v/ L# W- l$ E/ h% p0 [Sorafenib + sunitinib ?
# p1 k! Y3 e' C3 {* B2 Y1 YSorafenib + temsirolimus Yes, reduced dose
! H' K, q* A* o4 oSorafenib + everolimus Yes, reduced dose + _* }' @; u* m. ^
Sunitinib + temsirolimus† No
0 ^0 J3 ?' @/ k* k m5 lSunitinib + everolimus ? 8 `" L! f$ y' T2 `" B
Temsirolimus + everolimus ?
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†Led to US FDA warning.4 P; X5 _' d3 ^' a0 M+ F
?: As yet unattempted combination.
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