发给老马备查:3 m! `5 W3 z% U+ Z, N
滴水察海(69304838) 15:23:23. E( G; H/ ^" g. h. ~7 P
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱. q) l0 l$ Y2 `+ i
吉非替尼和S-1连用的依据+ J! w3 Y$ V0 m% }' \7 Z( ~1 r
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 s8 Z+ [: Y. K, m; n& v是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, ~, r+ ?1 ?9 E J6 y
这样是不是推理出,耐药后,可以用S-1和培美了?
% @& ~ t n: T2 _6 l: v4 G结论:
4 D3 F I4 ]- D如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |